Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites.

Overexpression of dre-miR-214 during development creates a curved-embryo phenotype which can also be created by disp2 knockdown. It was shown that miR-214 targets disp2 via 3 regions that show only loose pairing, in the same way that it targets Sufu.

[lab][connotea]

Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster

Genome alignment of Drosophila spp. 28% of the variation in D. melanogaster was in non-coding regions. One of these (DMAR 3R.463388) may represent an alteration of the 3'UTR of CG13716. One altered region, DMAR 3R.1966842 folds into a simple hairpin and my represent an unannotated miRNA. miRScan scored this with 11.48, and the region was shown to be expressed.
[lab][connotea]